A lack of efficacy.

synoniem: inefficaciousness.

Roget 732: failure; nonsuccess^†, nonfulfillment; dead failure, successlessness^†; abortion, miscarriage; brutum fulmen etc. 158 [Lat.]; labor in vain etc. (inutility) 645; no go; inefficacy^†; inefficaciousness etc. adj.; vain attempt, ineffectual attempt, abortive attempt, abortive efforts; flash in the pan, lame and impotent conclusion" [Othello]; frustration; slip 'twixt cup and lip etc. (disappointment) 509.    blunder etc. (mistake) 495; fault, omission, miss, oversight, slip, trip, stumble, claudication^†, footfall; false step, wrong step; faux pas [Fr.], titubation^†, b_evue [Fr.], faute [Fr.], lurch; botchery etc. (want of skill) 699^†; scrape, mess, fiasco, breakdown; flunk [U.S.].    mishap etc. (misfortune) 735; split, collapse, smash, blow, explosion.    repulse, rebuff, defeat, rout, overthrow, discomfiture; beating, drubbing; quietus, nonsuit^†, subjugation; checkmate, stalemate, fool's mate.    fall, downfall, ruin, perdition; wreck etc. (destruction) 162; deathblow; bankruptcy etc. (nonpayment) 808.    losing game, affaire flamb_ee.    victim; bankrupt; flunker^†, flunky [U.S.].    ... meer laten zien

Roget 158: impotence; inability, disability; disablement, impuissance, imbecility; incapacity, incapability; inaptitude, ineptitude, incompetence, unproductivity^†; indocility^†; invalidity, disqualification; inefficiency, wastefulness.    telum imbelle [Lat.], brutum fulmen [Lat.], blank, blank cartridge, flash in the pan, vox et proeterea nihil [Lat.], dead letter, bit of waste paper, dummy; paper tiger; Quaker gun.    inefficacy etc. (inutility) 645^†; failure etc. 732.    helplessness etc. adj.; prostration, paralysis, palsy, apoplexy, syncope, sideration^†, deliquium [Lat.], collapse, exhaustion, softening of the brain, inanition; emasculation, orchiotomy [Med.], orchotomy [Med.].    cripple, old woman, muff, powder puff, creampuff, pussycat, wimp, mollycoddle; eunuch.    ... meer laten zien

Roget 645: inutility; uselessness etc. adj.; inefficacy^†, futility; ineptitude, inaptitude; unsubservience^†; inadequacy etc. (insufficiency) 640; inefficiency, etc. (incompetence) 158; unskillfulness etc. 699; disservice; unfruitfulness etc. (unproductiveness).. 169; labor in vain, labor lost, labor of Sisyphus; lost trouble, lost labor; work of Penelope; sleeveless errand, wild goose chase, mere farce.    tautology etc. (repetition) 104; supererogation etc. (redundancy) 641.    vanitas vanitatum [Lat.], vanity, inanity, worthlessness, nugacity^†; triviality etc. (unimportance) 643.    caput mortuum [Lat.], waste paper, dead letter; blunt tool.    litter, rubbish, junk, lumber, odds and ends, cast-off clothes; button top; shoddy; rags, orts^†, trash, refuse, sweepings, scourings, offscourings^†, waste, rubble, debris, detritus; stubble, leavings; broken meat; dregs etc. (dirt) 653; weeds, tares; rubbish heap, dust hole; rudera^†, deads^†.    fruges consumere natus [Lat.] [Horace]. etc. (drone) 683 ... meer laten zien